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KMID : 1189420060190010021
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2006 Volume.19 No. 1 p.21 ~ p.30
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The Effect of Bangpungtongsung-San on Model of Allergic Rhinitis
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Kim Hee-Jeong
Kim Yoon-Bum
Park Owe-Suk
Kim Kyu-Seok
Cha Jae-Hoon
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Abstract
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Background and Objective: Allergic rhinitis is a IgE-mediated hypersensitive reaction at nasal mucosa. In oriental medicine, Bangpungtongsung-San is clinically widely used for the treatment of the allergic rhinitis. The objective of this study is to investigate the effects of Bangpungtongsung-San on allergic rhinitis experimentally.
Material and Methods: BALB/c mouse were divided into there groups: intact, control, experimental groups. Control and experimental group were induced allergic rhinitis by Ovalbumin as· the method of Levin and Vaz. Experimental group was orally administered the Bangpungtongsung-San for 28days. Total IgE, Interleukin-4, Interleukin-5 and Interferon-r were measured at three groups. The statistical significance was examined by Independent Samples T test.
Results: 1. The experimental group shows increase of IFN-r by 17% compared with control group but there was no statistical significance. 2. The experimental group shows increase of IL-4 and IL-5 compared with control group but there was no statistical significance. 3. The experimental group shows increase of Total IgE and diminution of OVA-specific IgE by 32% compared with control group but there was no statistical significance.
Conclusion: The effect of Bangpungtongsung-San on allergic rhinitis is not immunological but seems to be anti-imflammatory and anti-stress effect.
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KEYWORD
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AllergicRhinitis, Bangpungtongsung-San, IFL-r, IL-4, IL-5, IgE, anti-stress
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